The KEDRAB Formulary Monograph provides detailed information about the rabies virus (RABV) and how it damages the nervous system, vectors for infection, current PEP guidelines, a complete description of the efficacy and safety of KEDRAB® (Rabies Immune Globulin [Human]), and how KEDRAB should be used in PEP for rabies.
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PEP can prevent death due to rabies infection. For every patient not previously vaccinated against rabies, PEP should include wound cleansing, passive immunization with human rabies immune globulin (HRIG), and administration of rabies vaccine.7 Every year, an estimated 55,000 people in the United States receive PEP after contact with a possibly rabid animal.8
References: 1. Data on file. Kamada Ltd. 2. Scott TP, Nel LH. Subversion of the immune response by rabies virus. Viruses. 2016;8(8):231. 3. World Health Organization. Media centre rabies fact sheet. http://www.who.int/mediacentre/factsheets/fs099/en/. Updated April 2020. Accessed October 19, 2020. 4. Ghosh JB, Roy M, Lahiri K, Bala AK, Roy M. Acute flaccid paralysis due to rabies. J Pediatr Neurosci. 2009;4(1):33-35. 5. Rupprecht C, Kuzmin I, Meslin F. Lyssaviruses and rabies: current conundrums, concerns, contradictions and controversies. F1000Research. 2017;6(F1000 Faculty Rev):184. doi:10.12688/f1000research.10416.1. 6. Centers for Disease Control and Prevention. Learning about bats and rabies. https://www.cdc.gov/rabies/bats/education/. Updated April 22, 2011. Accessed October 19, 2020. 7. Centers for Disease Control and Prevention. Use of a reduced (4-dose) vaccine schedule for postexposure prophylaxis to prevent human rabies: recommendations of the Advisory Committee on Immunization Practices. MMWR Morb Mortal Wkly Rep. 2010;59(2):1-9. 8. Centers for Disease Control and Prevention. The burden of rabies. https://www.cdc.gov/Features/dsRabies/index.html. Updated September 26, 2016. Accessed October 19, 2020. 9. KEDRAB [package insert]. Fort Lee, NJ: Kedrion Biopharma Inc.; 2021.